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SECRETed

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About the project

SECRETed is an EU-H2020 multidisciplinary project involving multiple stakeholders and with a strong participation of SMEs to fully exploit the potential of aquatic biotechnology and produce novel industrial products for the agrochemical, pharmaceutical, cosmetic and chemistry sectors. SECRETed will develop novel hybrid molecules with tailor-made properties obtained from the combination of biosynthetic genes of amphiphilic compounds (biosurfactants and siderophores) produced by marine and extremophilic microorganisms. The project will focus on reutilizing previous sampling efforts by screening already collected microbial collections from previous European initiatives. Machine Learning algorithms (ML) will be deployed to reveal the genetic mechanisms responsible for their biosynthesis and to expand the chemical diversity of such bio-based compounds. To this end, databases inspection and new collected data will be employed to construct a unique microbial amphiphilic compound chemical space comprehending molecular structures, physicochemical characteristics, associated bioactivities and revealed genetic mechanisms responsible for their biosynthesis. To expand the chemical diversity and enhance the industrial sustainable exploitation of such bio-based compounds, Biosynthetic gene clusters (BGCs) in charge of the production of these molecules will be reverse engineered by standardizing and modularizing the genetic elements comprising such clusters. Their potential benefits will be broadened by looking for Industry-driven (agrochemical, cosmetic, nutrition and health) formulations based on the engineered combinations of the genetic elements expressed in suitable microbial hosts. New strains will then be designed, built and tested in an iterative process for the development of viable and sustainable industrial processes.

Project information

Grant agreement ID: 101000794

Start date

01 Jun

End date

31 May 2021

IDENER RESEARCH & DEVELOPMENT AGRUPACION DE INTERES ECONOMICO (Coordinator)

PHARMAMAR, S.A.

ACCUPLEX DIAGNOSTICS LTD

MATIS OHF

STAZIONE ZOOLOGICA ANTON DOHRN

ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON

EBERHARD KARLS UNIVERSITAET TUEBINGEN

BLUE SYNERGY SL

BIO BASE EUROPE PILOT PLANT VZW

SPHERA ENCAPSULATION SRL

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

UNIVERSIDAD DE SEVILLA

LUNDS UNIVERSITET

EXELISIS IKE

SYLENTIS SAU

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