background-page-title

Scientific Publications

Evaluation of ingredients for specific applications: an in vitro skin tolerance approach

products-right products-right
background-page-title

18 March 2022

Initially driven by legislative and ethical concerns, there is nowadays no doubt that reconstructed human epithelia model is a useful tool as preclinical test for assessing the tolerance of cosmetic or personal care products and ingredients as well. Depending on the legislation and the need of each geographic zone, dermopharmaceutical or cosmetic producers develop suitable formulations for specific applications onto human external mucous membranes or for sensitive target populations, such as products for intimate use, oral care or baby products. There is consequently a need for the ingredient suppliers to build an in vitro testing strategy in order to provide more targeted tolerance data for manufacturers and help them to select well tolerated ingredients.

The goal of this study was to investigate the behavior of key versatile cosmetic raw materials, at appropriate use levels, with different reconstructed human epithelia models. Even if these screening models are not including all markers and physiological specificities of humans, they estimate the tolerance of ingredients and products on the target epithelia tested.

For more information, the full article is available here

Alicia Roso - SEPPIC

Mickael Puginier - SEPPIC

Mathilde Bergal - SEPPIC

Frederic Nunzi - SEPPIC

Alain Alonso - SEPPIC

Cookies Policy

EnXylaScope Project may use cookies to memorise the data you use when logging to EnXylaScope website, gather statistics to optimise the functionality of the website and to carry out marketing campaigns based on your interests.

They allow you to browse the website and use its applications as well as to access secure areas of the website. Without these cookies, the services you have requested cannot be provided.
These cookies are necessary to allow the main functionality of the website and they are activated automatically when you enter this website. They store user preferences for site usage so that you do not need to reconfigure the site each time you visit it.
These cookies direct advertising according to the interests of each user so as to direct advertising campaigns, taking into account the tastes of users, and they also limit the number of times you see the ad, helping to measure the effectiveness of advertising and the success of the website organisation.

Required Cookies They allow you to browse the website and use its applications as well as to access secure areas of the website. Without these cookies, the services you have requested cannot be provided.

Functional Cookies These cookies are necessary to allow the main functionality of the website and they are activated automatically when you enter this website. They store user preferences for site usage so that you do not need to reconfigure the site each time you visit it.

Advertising Cookies These cookies direct advertising according to the interests of each user so as to direct advertising campaigns, taking into account the tastes of users, and they also limit the number of times you see the ad, helping to measure the effectiveness of advertising and the success of the website organisation.