18 March 2022

Initially driven by legislative and ethical concerns, there is nowadays no doubt that reconstructed human epithelia model is a useful tool as preclinical test for assessing the tolerance of cosmetic or personal care products and ingredients as well. Depending on the legislation and the need of each geographic zone, dermopharmaceutical or cosmetic producers develop suitable formulations for specific applications onto human external mucous membranes or for sensitive target populations, such as products for intimate use, oral care or baby products. There is consequently a need for the ingredient suppliers to build an in vitro testing strategy in order to provide more targeted tolerance data for manufacturers and help them to select well tolerated ingredients.

The goal of this study was to investigate the behavior of key versatile cosmetic raw materials, at appropriate use levels, with different reconstructed human epithelia models. Even if these screening models are not including all markers and physiological specificities of humans, they estimate the tolerance of ingredients and products on the target epithelia tested.

For more information, the full article is available here